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Source: http://feedproxy.google.com/~r/Techcrunch/~3/NNH6h886o2U/
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Feb. 27, 2013 ? For the first time, scientists have shown that transplanted eyes located far outside the head in a vertebrate animal model can confer vision without a direct neural connection to the brain.
Biologists at Tufts University School of Arts and Sciences used a frog model to shed new light -- literally -- on one of the major questions in regenerative medicine, bioengineering, and sensory augmentation research.
"One of the big challenges is to understand how the brain and body adapt to large changes in organization," says Douglas J. Blackiston, Ph.D., first author of the paper "Ectopic Eyes Outside the Head in Xenopus Tadpoles Provide Sensory Data For Light-Mediated Learning," in the February 27 issue of the Journal of Experimental Biology. "Here, our research reveals the brain's remarkable ability, or plasticity, to process visual data coming from misplaced eyes, even when they are located far from the head."
Blackiston is a post-doctoral associate in the laboratory of co-author Michael Levin, Ph.D., professor of biology and director of the Center for Regenerative and Developmental Biology at Tufts University.
Levin notes, "A primary goal in medicine is to one day be able to restore the function of damaged or missing sensory structures through the use of biological or artificial replacement components. There are many implications of this study, but the primary one from a medical standpoint is that we may not need to make specific connections to the brain when treating sensory disorders such as blindness."
In this experiment, the team surgically removed donor embryo eye primordia, marked with fluorescent proteins, and grafted them into the posterior region of recipient embryos. This induced the growth of ectopic eyes. The recipients' natural eyes were removed, leaving only the ectopic eyes.
Fluorescence microscopy revealed various innervation patterns but none of the animals developed nerves that connected the ectopic eyes to the brain or cranial region.
To determine if the ectopic eyes conveyed visual information, the team developed a computer-controlled visual training system in which quadrants of water were illuminated by either red or blue LED lights. The system could administer a mild electric shock to tadpoles swimming in a particular quadrant. A motion tracking system outfitted with a camera and a computer program allowed the scientists to monitor and record the tadpoles' motion and speed.
Eyes See Without Wiring to Brain
The team made exciting discoveries: Just over 19 percent of the animals with optic nerves that connected to the spine demonstrated learned responses to the lights. They swam away from the red light while the blue light stimulated natural movement.
Their response to the lights elicited during the experiments was no different from that of a control group of tadpoles with natural eyes intact. Furthermore, this response was not demonstrated by eyeless tadpoles or tadpoles that did not receive any electrical shock.
"This has never been shown before," says Levin. "No one would have guessed that eyes on the flank of a tadpole could see, especially when wired only to the spinal cord and not the brain." The findings suggest a remarkable plasticity in the brain's ability to incorporate signals from various body regions into behavioral programs that had evolved with a specific and different body plan.
"Ectopic eyes performed visual function," says Blackiston. "The brain recognized visual data from eyes that impinged on the spinal cord. We still need to determine if this plasticity in vertebrate brains extends to different ectopic organs or organs appropriate in different species."
One of the most fascinating areas for future investigation, according to Blackiston and Levin, is the question of exactly how the brain recognizes that the electrical signals coming from tissue near the gut is to be interpreted as visual data.
In computer engineering, notes Levin, who majored in computer science and biology as a Tufts undergraduate, this problem is usually solved by a "header" -- a piece of metadata attached to a packet of information that indicates its source and type. Whether electric signals from eyes impinging on the spinal cord carry such an identifier of their origin remains a hypothesis to be tested.
Research reported in this publication was supported by grants from the National Institute of Mental Health of the National Institutes of Health under award number MH081842-02 and the National Eye Institute, also of the NIH, under award number EY018168, and the Forsyth Institute, under award number 5T32DE007327-09.
Additional funders were the Leila Y. Mathers Charitable Foundation and the U.S. Army Medical Research and Materiel Command (USAMRMC, award W81XWH-10-2-0058).
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Actor-director Clint Eastwood is the latest prominent conservative to sign on to a court brief opposing a California gay marriage ban. Also, two NFL players have opposed a gay-marriage ban in a separate brief to the Supreme Court.
The news comes on the same day that President Barack Obama will file his own ?friend of the court? brief urging the Supreme Court to overturn Proposition 8, the ballot initiative that banned same-sex marriage in California.
The court is expected to hear the case on March 26. The justices will listen to arguments about a related case, the Defense of Marriage Act, on March 27.
Solicitor General Donald Verrilli will file the brief on behalf of the Obama administration.
More than 100 people with current or past connections to the Republican Party or conservative causes have signed briefs in the case.
The website Brietbart.com first reported that Eastwood signed the brief. Eastwood made national headlines this summer when he appeared at the Republican National Convention and spoke to an empty chair onstage.
On Tuesday, the American Foundation for Equal Rights said that more than 80 ?political and social conservatives? had signed the brief, and more signatures were expected.
Names on the brief include Mary Bono Mack, Gary Johnson, Jon Huntsman, William F. Weld, Christine Todd Whitman, and Meg Whitman.
Two prominent lawyers, Democrat David Boies and Republican Theodore B. Olson, will take the argument against Proposition 8 to the Supreme Court.
If those names sound familiar, it?s because they were also the top advocates in the 2000 Supreme Court case Bush v. Gore, with Olson representing George W. Bush and Boies representing Al Gore.
Another brief in the case was filed by two National Football League players, Chris Kluwe and Brendon Ayanbadejo.
?America?has walked this path before, and courageous people and the court brought us to the right result. We urge the court to repeat those actions here,? the athletes said in a brief that was filed this month.
The recent news of Republicans supporting gay marriage is, of course, in contrast to the stance of House Republican leaders. In February 2011, when the Obama administration announced it would no longer defend Section 3 of the Defense of Marriage Act (which is being considered in another case, Windsor v. United States), the Bipartisan Legal Advisory Panel of the House voted to stand in to defend the law.
The court is expected to announce a decision in the Proposition 8 case in June.
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Source: http://news.yahoo.com/clint-eastwood-nfl-players-offer-support-gay-marriage-211611460--politics.html
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Feb. 27, 2013 ? A novel fabrication technique developed by UConn engineering professor Brian Willis could provide the breakthrough technology scientists have been looking for to vastly improve today's solar energy systems.
For years, scientists have studied the potential benefits of a new branch of solar energy technology that relies on incredibly small nanosized antenna arrays that are theoretically capable of harvesting more than 70 percent of the sun's electromagnetic radiation and simultaneously converting it into usable electric power.
The technology would be a vast improvement over the silicon solar panels in widespread use today. Even the best silicon panels collect only about 20 percent of available solar radiation, and separate mechanisms are needed to convert the stored energy to usable electricity for the commercial power grid. The panels' limited efficiency and expensive development costs have been two of the biggest barriers to the widespread adoption of solar power as a practical replacement for traditional fossil fuels.
But while nanosized antennas have shown promise in theory, scientists have lacked the technology required to construct and test them. The fabrication process is immensely challenging. The nano-antennas -- known as "rectennas" because of their ability to both absorb and rectify solar energy from alternating current to direct current -- must be capable of operating at the speed of visible light and be built in such a way that their core pair of electrodes is a mere 1 or 2 nanometers apart, a distance of approximately one millionth of a millimeter, or 30,000 times smaller than the diameter of human hair.
The potential breakthrough lies in a novel fabrication process called selective area atomic layer deposition (ALD) that was developed by Willis, an associate professor of chemical and biomolecular engineering and the previous director of UConn's Chemical Engineering Program. Willis joined UConn in 2008 as part of an eminent faculty hiring initiative that brought an elite team of leaders in sustainable energy technology to the University. Willis developed the ALD process while teaching at the University of Delaware, and patented the technique in 2011.?
It is through atomic layer deposition that scientists can finally fabricate a working rectenna device. In a rectenna device, one of the two interior electrodes must have a sharp tip, similar to the point of a triangle. The secret is getting the tip of that electrode within one or two nanometers of the opposite electrode, something similar to holding the point of a needle to the plane of a wall. Before the advent of ALD, existing lithographic fabrication techniques had been unable to create such a small space within a working electrical diode. Using sophisticated electronic equipment such as electron guns, the closest scientists could get was about 10 times the required separation. Through atomic layer deposition, Willis has shown he is able to precisely coat the tip of the rectenna with layers of individual copper atoms until a gap of about 1.5 nanometers is achieved. The process is self-limiting and stops at 1.5 nanometer separation.
The size of the gap is critical because it creates an ultra-fast tunnel junction between the rectenna's two electrodes, allowing a maximum transfer of electricity. The nanosized gap gives energized electrons on the rectenna just enough time to tunnel to the opposite electrode before their electrical current reverses and they try to go back. The triangular tip of the rectenna makes it hard for the electrons to reverse direction, thus capturing the energy and rectifying it to a unidirectional current.
Impressively, the rectennas, because of their incredibly small and fast tunnel diodes, are capable of converting solar radiation in the infrared region through the extremely fast and short wavelengths of visible light -- something that has never been accomplished before. Silicon solar panels, by comparison, have a single band gap which, loosely speaking, allows the panel to convert electromagnetic radiation efficiently at only one small portion of the solar spectrum. The rectenna devices don't rely on a band gap and may be tuned to harvest light over the whole solar spectrum, creating maximum efficiency.
The federal government has taken notice of Willis's work. Willis and a team of scientists from Penn State Altoona along with SciTech Associates Holdings Inc., a private research and development company based in State College, Pa., recently received a $650,000, three-year grant from the National Science Foundation to fabricate rectennas and search for ways to maximize their performance.
"This new technology could get us over the hump and make solar energy cost-competitive with fossil fuels," says Willis. "This is brand new technology, a whole new train of thought."
The Penn State Altoona research team -- which has been exploring the theoretical side of rectennas for more than a decade -- is led by physics professor Darin Zimmerman, with fellow physics professors Gary Weisel and Brock Weiss serving as co-investigators. The collaboration also includes Penn State emeritus physics professors Paul Cutler and Nicholas Miskovsky, who are principal members of Scitech Associates.
"The solar power conversion device under development by this collaboration of two universities and an industry subcontractor has the potential to revolutionize green solar power technology by increasing efficiencies, reducing costs, and providing new economic opportunities," Zimmerman says.
"Until the advent of selective atomic layer deposition (ALD), it has not been possible to fabricate practical and reproducible rectenna arrays that can harness solar energy from the infrared through the visible," says Zimmerman. "ALD is a vitally important processing step, making the creation of these devices possible. Ultimately, the fabrication, characterization, and modeling of the proposed rectenna arrays will lead to increased understanding of the physical processes underlying these devices, with the promise of greatly increasing the efficiency of solar power conversion technology."
The atomic layer deposition process is favored by science and industry because it is simple, easily reproducible, and scalable for mass production. Willis says the chemical process is already used by companies such as Intel for microelectronics, and is particularly applicable for precise, homogenous coatings for nanostructures, nanowires, nanotubes, and for use in the next generation of high-performing semi-conductors and transistors.
Willis says the method being used to fabricate rectennas also can be applied to other areas, including enhancing current photovoltaics (the conversion of photo energy to electrical energy), thermoelectrics, infrared sensing and imaging, and chemical sensors.
A 2011 seed grant from UConn's Center for Clean Energy Engineering allowed Willis to fabricate a prototype rectenna and gather preliminary data using ALD that was instrumental in securing the NSF grant, Willis says.
Over the next year, Willis and his collaborators in Pennsylvania plan to build prototype rectennas and begin testing their efficiency. Willis compares the process to tuning in a station on a radio.
"We've already made a first version of the device," says Willis. "Now we're looking for ways to modify the rectenna so it tunes into frequencies better. I compare it to the days when televisions relied on rabbit ear antennas for reception. Everything was a static blur until you moved the antenna around and saw the ghost of an image. Then you kept moving it around until the image was clearer. That's what we're looking for, that ghost of an image. Once we have that, we can work on making it more robust and repeatable."
Willis says finding that magic point where a rectenna picks up maximum solar energy and rectifies it into electrical power will be the champagne-popping, "ah-ha" moment of the project.
"To capture the visible light frequencies, the rectenna have to get smaller than anything we've ever made before, so we're really pushing the limits of what we can do," says Willis. "And the tunnel junctions have to operate at the speed of visible light, so we're pushing down to these really high speeds to the point where the question becomes 'Can these devices really function at this level?' Theoretically we know it is possible, but we won't know for sure until we make and test this device."
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The above story is reprinted from materials provided by University of Connecticut. The original article was written by Colin Poitras.
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CHICAGO (AP) ? The president of a cancer charity founded by Lance Armstrong insists that the organization will persevere in the wake of the cyclist's admission that he used performance-enhancing drugs.
The Livestrong Foundation's president, Doug Ulman, was scheduled to deliver what the organization described as a "major 'State of the Foundation' speech" on Thursday in Chicago.
"Our success has never been based on one person," Ulman said in remarks prepared for the annual gathering of Livestrong charity leaders, grantees and others. "Will the Livestrong Foundation survive? Yes. Absolutely, yes. Hell, yes."
Armstrong stepped down as chairman of the charity in October, saying he didn't want his association to damage the foundation's ability to raise money and continue its advocacy programs on behalf of people with cancer.
Originally called the Lance Armstrong Foundation, the cyclist created the organization in Austin, Texas, a year after he was diagnosed with testicular cancer that had spread to his brain and lungs. Doctors gave him 50-50 odds of surviving.
Armstrong admitted during an interview with Oprah Winfrey this year that he used performance-enhancing drugs when he won seven straight Tour de France titles. He told Winfrey that leaving Livestrong was the most "humbling" experience after the revelations about his drug use broke.
"I wouldn't at all say forced out, told to leave," he told Winfrey about Livestrong. "I was aware of the pressure. But it hurt like hell.
"That was the lowest," Armstrong said. "The lowest."
Armstrong's personal fortune had sustained a big hit days earlier. One by one, his sponsors called to end their associations with him: Nike; Trek Bicycles; Giro, which manufactures cycling helmets and other accessories; Anheuser-Busch.
"That was a $75 million day," Armstrong said.
"That just went out of your life," Winfrey said.
"Gone," he replied.
___
Follow Michael Tarm at www.twitter.com/mtarm
Source: http://news.yahoo.com/charity-once-tied-armstrong-says-survive-135912093--spt.html
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Following a closed-door party caucus, House Speaker John Boehner of Ohio, accompanied by fellow GOP leaders, meet with reporters, on Capitol Hill in Washington, Tuesday, Feb. 26, 2013, to challenge President Obama and the Senate to avoid the automatic spending cuts set to take effect in four days. Speaking at the Republican National Committee headquarters, Boehner complained that the House, with Republicans in the majority, has twice passed bills that would replace the across-the-board cuts known as the "sequester" with more targeted reductions, while the Senate, controlled by the Democrats, has not acted. From left are, Rep. Lynn Jenkins, R-Kansas, Rep. Cathy McMorris Rodgers, R-Wash., Boehner, and House Majority Leader Eric Cantor of Va. (AP Photo/J. Scott Applewhite)
Following a closed-door party caucus, House Speaker John Boehner of Ohio, accompanied by fellow GOP leaders, meet with reporters, on Capitol Hill in Washington, Tuesday, Feb. 26, 2013, to challenge President Obama and the Senate to avoid the automatic spending cuts set to take effect in four days. Speaking at the Republican National Committee headquarters, Boehner complained that the House, with Republicans in the majority, has twice passed bills that would replace the across-the-board cuts known as the "sequester" with more targeted reductions, while the Senate, controlled by the Democrats, has not acted. From left are, Rep. Lynn Jenkins, R-Kansas, Rep. Cathy McMorris Rodgers, R-Wash., Boehner, and House Majority Leader Eric Cantor of Va. (AP Photo/J. Scott Applewhite)
Air Force personnel salute as Air Force One, with President Barack Obama on board, arrives at in the rain at Andrews Air Force Base, Md., Tuesday, Feb. 26, 2013. The president was returning from Newport News, Va., for an event on the automatic budget cuts. (AP Photo/Susan Walsh)
Standing in front of a ships propeller, President Barack Obama gestures as he speaks about about automatic defense budget cuts, Tuesday, Feb. 26, 2013, at Newport News Shipbuilding in Newport News, Va. (AP Photo/Steve Helber)
House Speaker John Boehner of Ohio, accompanied by fellow members of the House GOP leadership, responds to President Barack Obama's remarks to the nation's governors earlier today about how to fend off the impending automatic budget cuts, Monday, Feb. 25, 2013, on Capitol Hill in Washington. (AP Photo/J. Scott Applewhite)
WASHINGTON (AP) ? America's leaders have threatened to shut the government down, drive it over a cliff and bounce it off the ceiling. Now they're ready to smack it with a "sequester." And it looks like they mean it this time.
Big, scary-sounding cuts in federal spending are set to begin Friday. Should Americans be worried?
A primer on the nation's latest fiscal standoff ? how we got here, who could get hurt and possible ways to end this thing:
___
What, again?
Like life in a bad Road Runner cartoon, the United States has survived the New Year's "fiscal cliff," double rounds of debt-ceiling roulette and various budget blow-ups over the past two years. Now the threat is $85 billion in indiscriminate spending cuts that would hit most federal programs and fall hardest on the military. Pentagon programs are slated for an 8 percent cut; other agencies would lose 5 percent for the current budget year.
By law, these cuts known as the "sequester" begin unfolding automatically at week's end unless President Barack Obama and Congress act to stop them. Even after they've begun, the cuts still could be halted or reversed through legislation.
Why did Congress and Obama agree to automatic cuts they don't like? To corner themselves into getting the nation's deficit under control.
___
Isn't deficit-cutting good?
Obama, nearly all of Congress and plenty of economists say two things:
1) The budget deficit needs to be reduced.
2) The sequester is the wrong way to do it.
"Only a fool would do it this way," says Paul Light, a budget expert at New York University. "Primordial. It's beyond belief."
It makes him think of the movie "Dr. Strangelove," with Slim Pickens riding bronco on an atomic bomb, waving his cowboy hat.
The sequester was designed to land with a mighty splat ? to create such a mess if allowed to occur that lawmakers would do the right and honorable thing and negotiate a measured, meaningful and discerning package of deficit reduction to head it off. But that didn't happen, so the sequester is about to.
And, yes, that should mean progress on the nation's debt. The sequester is one of several developments expected to restrain the nation's red ink after four straight years of deficits topping $1 trillion.
Yee-haw.
___
Are the cuts really that bad?
It's unlikely they will be as bad ? or at least as immediate ? as some overexcited members of the Obama administration have made out. But the cuts have the potential to be significant if the standoff drags on.
Early on, about 2 million long-term unemployed people could see a $30 cut in benefit checks now averaging $300 a week. Federal subsidies for school construction, clean energy and state and local public works projects could be pinched. Low-income pregnant women and new mothers may find it harder to sign up for food aid.
Much depends on how states and communities manage any shortfalls in aid from Washington.
Furloughs of federal employees are for the most part a month or more away. Then, they might have to take up to a day off per week without pay.
That's when the public could start seeing delays at airports, disruptions in meat inspection, fewer services at national parks and the like.
An impasse lasting into the fall would reach farther, probably shrinking Head Start slots, for example.
Much of the federal budget is off-limits to the automatic cuts. Among exempted programs: Social Security, Medicaid, food stamps, Pell Grants and veterans' programs.
Even so, officials warn of a hollowed-out military capability, compromised border security and spreading deterioration of public services if the sequester continues. It's "like a rolling ball," said Homeland Security Secretary Janet Napolitano. "It keeps growing."
___
Maybe it's fiscal-crisis fatigue.
So far, Americans have yawned this one off. Only 27 percent of those surveyed for a Pew Research Center/USA Today poll last week said they had heard a lot about the looming automatic spending cuts.
Less than a third think the budget cuts would deeply affect their own financial situation, according to a Washington Post poll. Sixty percent, however, believe the cuts would have a major effect on the U.S. economy.
That's what economists and business people are nervous about.
The political standoff is the factor that economists blame most for the slowing economy, according to the latest Associated Press Economic Survey. The uncertainty about future government spending is causing businesses to hold back on investment and hiring, and it's making consumers less confident about their own spending, economists warn.
___
How did it come to this?
Obama and congressional Republicans have been deadlocked over spending since the GOP won control of the House in 2010, with a big boost from tea party activists who champion lower taxes and an end to red-ink budgets.
House Republicans refused to raise the nation's borrowing limit in 2011 without major deficit cuts. To resolve the stalemate, Congress passed and Obama signed the Budget Control Act, which temporarily allowed borrowing to resume, set new spending limits and created a bipartisan "supercommittee" to recommend at least $1.2 trillion more in deficit reduction over 10 years. Republicans and Democrats on the supercommittee failed to compromise, however.
That triggered the law's doomsday scenario ? the so-called "fiscal cliff" package of across-the-board tax increases and spending cuts.
In a New Year's Eve deal, Obama and Congress agreed to raise taxes on some of the nation's wealthiest earners. And they postponed the spending cuts for two months ? until Friday.
That was supposed to buy time for a deal.
___
But there's still no deal.
Obama and congressional leaders have scheduled talks for Friday, the day the automatic cuts begin taking effect. Democrats and Republicans still look far apart, however.
Obama insists on blending spending cuts with targeted tax increases. Republican leaders reject any more tax increases and want to shear spending while protecting the military's budget.
While both sides talk about reducing the deficit, Obama and other Democrats say this must be done gradually, to avoid wounding an already weak economy.
The president has been taking his case to the people, blasting Republicans at campaign-style events. GOP leaders, just back from last week's congressional vacation, are grousing that Obama should be bargaining with them, not grandstanding.
___
Is there a way out?
Expect negotiations to intensify if enough Americans begin yelping about the pain from reduced federal spending.
Obama and Congress could agree to pare down the budget cuts to a more logical package of reductions, perhaps with some tax changes, too. Such a deal could also retroactively restore the missed spending where they want to.
The "sequester" isn't the only line in the sand, however.
On March 27, legislation that has been temporarily financing the government expires. Without agreement to extend it, the threat of a partial government shutdown looms. Later in the spring, it will be time to raise the nation's debt limit again.
So far, two years of budget crises have been settled with temporary fixes. They have barely dented the underlying disagreement over how to reform Medicare, Social Security, taxes and spending to address the nation's long-term deficit problem.
If those festering questions remain unanswered, the U.S. economy will remain a hostage to politics.
___
AP Director of Polling Jennifer Agiesta contributed to this report.
___
Follow Connie Cass on Twitter: http://www.twitter.com/ConnieCass
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Rosa Golijan TODAY
1 hour ago
On The Rebound
"Yes, it's creepy," admits the man who co-created an app that goes through up to six years of your Facebook friends' relationship histories to determine who's ready for a new significant other. "Of course it's creepy!"
"But here's the thing," Anthony Coombs, who created the On The Rebound Facebook app with two friends, continued. "Let's be honest. You meet someone. If you friend them on Facebook, the first thing you do is check their relationship status. You're going to check and see if they are single ... and then creepily troll through their profile."
"Instead of taking the time to do this on a lonely Thursday or Friday .... we'll do this for you," the 32-year-old added, the slightest bit of a smile in his voice.
Coombs came up with the idea for On The Rebound after a missed opportunity. He'd been interested in a girl for the longest time, but she was already in a relationship. "I was the confidant, someone she talked to," he explained. "When the relationship ended, I specifically did not ask her out [...] I'm aware of when people are on the rebound." So he waited for his romantic interest to be ready for a new relationship.
On The Rebound
Unfortunately Coombs waited too long. "I'm not sure how long I waited," he said, "but during this time she ended up hooking up with a guy I knew and they're still together."
When Coombs shared the tale with his friend Jon Tran, the latter immediately started wondering about how someone could use data to figure out when people are most likely to enter a relationship. Together with designer Taylor Lecroy, the two started working on an app the same night.
Over the course of the next two-and-a-half months, the men interviewed relationships experts across the country to figure out how age and gender affect relationships. "People of different ages, who are at different stages in life, react differently to relationships ending," Coombs explained, "and relationship length matters, too."
On The Rebound sifts through relationship data when you connect it to your Facebook account and then it spits out a detailed breakdown of your friends' romantic histories. How long have they been single? Have they had a large number of relationships in the last year? How long does it take, on average, before they jump from one to the next? Based on all this information and some magical formulas, On The Rebound can assign "Rebound Ratings" to your pals and offer advice. "Hopefully he's moved on from his ex by now," the app might point out regarding one friend. "Trust me, he's using you," it might say about another "Use him back!"
Of course, as a disclaimer on the On The Rebound website cautions, the app "is for entertainment purposes only" ? so be careful about following all of its advice to the letter.
Want more tech news or interesting links? You'll get plenty of both if you keep up with Rosa Golijan, the writer of this post, by following her on Twitter, subscribing to her Facebook posts, or circling her on Google+.
Source: http://www.today.com/tech/creepy-facebook-app-tells-you-which-friends-date-1C8624099
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